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Using too much nicotine, especially if you're not accustomed to it, can lead to an uncomfortable nicotine "high." This occurs if you consume more nicotine than your body can take, often from using higher-strength products or taking multiple doses too close together

While donor smoking history was linked to a statistically significant reduction in forced expiratory volume in 1 second (FEV1) in double lung transplant recipients one year after transplant, this effect was not clinically significant. The number of donor lungs available for transplantation is limited, which makes it crucial to strike the right balance between avoiding unnecessary limits on the donor pool and still identifying the most suitable donors

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In esophageal and lung cancers, mutp53 suppresses SLC7A11 expression by interacting with the master antioxidant transcription factor NRF2, which promotes the accumulation of ROS and induces ferroptosis [79]