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Biofilm cells exhibit collective phenotypes that differ from planktonic cells including altered metabolism, increased stress response, altered cell surface properties, and the secretion of a protective extracellular matrix (ECM) creating a niche environment, together all these factors contribute to their enhanced tolerance to antifungal therapy and immune clearance (Nett and Andes, 2020

Impaired Detoxification : Lower glutathione levels can hinder the bodys detoxification processes, making it more challenging to eliminate toxins and waste products

The elabela-APJ axis could mitigate neuronal ferroptosis following ischemic stroke, and the ELA-32 peptide may be a potential therapeutic candidate for ischemic stroke and cardiovascular diseases

10.1016/j.freeradbiomed.2009.03.016 127 TsatsanisA.WongB