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The distribution functions and detailed calculation methodology is specified in Supplementary Tables S1S2 online

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Norepinephrine and Nicotine Withdrawal Clinical and preclinical studies suggest that noradrenergic transmission plays a role in tobacco and nicotine withdrawal

However, cytisinicline used for vaping cessation does not appear to increase the risk of relapse to smoking or dual use, a finding consistent with cytisiniclines demonstrated efficacy for smoking cessation and its hypothesized method of action as a partial nicotine receptor agonist that blocks the reinforcement of smoking, they wrote