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Biological and molecular bases of mammary carcinogenesis Lab Invest 1987 57 : 112137 Wiencke J, Pemble S, Ketterer B, Kelsey K

Hydrophobic peptides or peptides rich in basic amino acids such as arginine, lysine or histidine may require an acidic first step solvent to support full dissolution

However, when studied, peptides like Receptor Grade IGF-1 LR3 appeared to induce glucose uptake not just through IGF-1 receptor interactions but also independently, possibly via other pathways or receptors