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Margin of Exposure (MOE) calculation for synthetic cooling agents MOE, a preferred risk assessment parameter for toxic compounds by the JECFA 34 , 35 , was calculated for WS-3 and WS-23 containing E-liquids using the following formula, as described previously: 36 Where NOAEL is the No-Observed-Adverse-Effect-Level, a dose determined as the threshold producing a toxic effect in animal oral toxicity studies

My role quickly became the media darling for the academics, statisticians, physicians, and health care educators as my approach with kids was the same as when I was the role model to get them to do something they never really wanted to do as a young child, he told interviewer James Dunworth in 2011