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26 Engaging adolescents, employing brief interventions that promote self-management and referring to youth drug and alcohol, community mental health and paediatric services are often needed early in the drug use spectrum to prevent substance misuse and to achieve positive behaviour change (Box 5)

One study found that significant labeling issues were detectedwith high concentrations of nicotine [in products] labeled not to contain nicotine, further necessitating strict standard operating procedures

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Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article