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Subjects that smoked higher numbers of cigarettes exhibited greater decreases in hippocampal volume, and relatively higher memory scores (although memory was still generally poorer than in all other groups)

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In Study 1, the C max and overall nicotine uptake after Velo Pouch use was associated with nicotine content level, in agreement with other studies in which ONPs with a high nicotine content exhibited C max and AUC comparable to or higher than those of cigarettes ( max and AUC values