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Chronic exposure to tobacco smoke or nicotine leads to tolerance to the physiological (e.g., decrease in heart rate and body temperature) and behavioral (e.g., decrease in locomotor activity and rearing) effects of nicotine and an upregulation of 42 and 7-containing nAChRs in rats and mice (Pauly et al., 1991

I'm fleshing out, fleshing out, fleshing out Don't wanna leave you behind So, baby, don't leave, don't leave, don't leave Don't leave, don't leave, don't leave Smoke me like a cigarette Burn it till you're wheezing Tell me that you love me even if you don't mean it Your blood, my blood, we bleed it Your bones, my bones break even Smoke me like a cigarette Burn it till you're wheezing Tell me that you love me even if you don't mean it Used to think I loved you, but now it's over Scars all over my skin and on my body, I don't know ya Tell me that you love me, do you still need me

Tobacco Control, 14 , 8692

Liverpool is the UKs hotspot for the illegal cigarette trade