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37 This being said, the identified dose-dependent associations in diffuse brain areas (including regions without evidence for a role in impulse control) and the apparent reversal of the effect of smoking on the cortex provide evidence that the differences in thickness do not mostly predate the onset of smoking

They concluded that HTPs appear to have a better safety profile than cigarettes but suggested further long-term studies

As another group of researchers concluded earlier this year, after publishing a similar study in the journal Tobacco Control, these flavoring chemicals may be technically food-grade but that doesnt mean theyre safe to inhale.