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When you smoke, the chemicals irritate your blood vessels, leading to inflammation and swelling

Some have argued that the relatively high prevalence rates of mental disorders estimated in epidemiological surveys are unrealistic as specialist clinical services could not be provided to 20% of the population, and that the definition of mental disorders should be limited to those disorders severe enough to require clinical intervention or justify receipt of disability benefits [12, 45, 46]

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Changes in timing or triggers Reduced habitual patterns Individual Variation Responses differ significantly between patients