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In mammals, ferroptosis has been implicated in diverse pathologies, including neurodegenerative diseases, stroke, traumatic brain injury and kidney degeneration, as well as in carcinogenesis, where it may exert a tumor-suppressor function

Muscle-Specific Effects In skeletal muscle specifically, these signaling events promote muscle fiber hypertrophy (increased muscle cell size), activation and proliferation of satellite cells (muscle stem cells that can fuse with existing fibers or form new fibers), increased myofibrillar protein content and contractile capacity, and overall muscle mass accretion

doi: 10.1073/pnas.95.16.9220

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