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The A/J mouse strain is highly sensitive to toxicants/compounds that are carcinogenic, and exposure to these carcinogenic materials causes an increase in the number of animals that develop both adenomas and adenocarcinomas (incidence)

It has been reported that plasminogen activator inhibitor-1 gene expression in endothelial cells and vascular remodeling are normalized by ROCK inhibitor treatment in atherosclerosis models [83, 84]

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doi: 10.1136/tobaccocontrol-2012-050569