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Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells

At the same time, genome-wide loss of DNA methylation is observed in tumor cells compared to healthy cells inducing chromosomal instability, loss of imprinting as well as the previously described oncogene activation

In vitro coculture of NP and fibroblastic cells We used rat NP cells cocultured with mouse fibroblast L929 cells to imitate the in vivo cellular effects that fibroblasts may have on the NP cells within the intervertebral disc

The targeted cohort consisted of a total of 46 ventricular CSF samples, including 29 samples from the semi-targeted dataset together with 17 new samples ( Figure 3A)