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The 2016 revised statement on e-cigarettes by the US Flavoring and Extract Manufacturers Association about these chemicals (which have been safety assessed for use in foods and beverages, but not for inhalation) is further cause for concern: The manufacturers and marketers of e-cigarettes and all other flavored tobacco products, and flavor manufacturers and marketers, should not represent or suggest that the flavor ingredients used in these products are safe because they have FEMA GRASTM status for use in food because such statements are false and misleading

THE LANCET, probably the greatest medical publication in the world, very lately made an extensive collection of cigarettes of the world and had them analyzed by its own board of experts and the result has been made public

Samet says

their median of 25 cigs/day decreasing to 6 cigs/day (p 10 cigarettes/day