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Additionally, due to buprenorphines affinity for the mu receptor, use of potent opioids such as hydromorphone or fentanyl may be required to achieve adequate pain relief and should be considered and titrated to effect (this may be higher than for opiate-naive patients)

When taken sublingually, they can also take effect more rapidly than edibles

Specifically, the FDA recently sent final rules regarding the ban to the White House Office of Management and Budget (OMB) to review

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