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The intrinsic apoptotic pathway is regulated by the proteins of the B cell lymphoma 2 (BCL-2) family [7]

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Reubens went to great lengths to create distance between Pee-wee and his real life (the one time I met him in person he asked not to be photographed out of his Pee-wee costume), so seeing him talk openly about the character and his personal life in the same interview is a fascinating opportunity for his fans