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As of 2016, the FDA has extended regulations to e-cigarettes

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Subjects were then randomized by a block size of 3 to one of the IP sequences, (sequence[subjects]): (ABECD [3], BCADE [3], CDBEA [4], DECAB [3], EADBC [3], DCEBA [3], EDACB [4], AEBDC [3], BACED [3], and CBDAE [4]) to use one IP in each session