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Chacon says that overall, the most effective overall treatment for stubborn hyperpigmentation is often combination approach rather than a single over-the-counter cream
Despite poor correlation with AUC, TDM by measuring full blood concentration 12 (C12)- or 24 (C24) hours after administration is most commonly used and currently state of the art (63) and C2 plus C10 for AUC0-24 (64), but have not yet gained acceptance in clinical practice, mainly due to practical reasons (65)
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