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Patients typically take a dose of between 20 and 25 mg/kg/day, with an average seizure reduction of ~ 50% [7] and a mean serum concentration of ~ 125 ng/ml [8]

Anne was a remarkable person and culinary talent teaching, competing and always sharing the importance of food in her life and the joy that a delicious meal can bring

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Nevertheless, what makes TS so addictive is the primary psychoactive substance, nicotine, and this is based on how it acts nicotinic acetylcholine receptors and the release of the chemical dopamine, which is euphoric and reinforcing (Pontieri et al., 1996