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Nicotiana Rustica, sometimes known as Wild Tobacco, thuoc lao, mapacho and other regional names, is an incredibly strong variety of whole leaf tobacco with up to 9x more nicotine then other varieties of whole leaf tobacco

Tobacco has a long history in the Western Hemisphere, dating back well before the time when the first European explorers visited the Americas

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

Though at high doses, the substance is poisonous to cells, it can speed up the growth of cancerous cells in certain types of cancer and prevent their destruction, making them unnaturally long-lived