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128,132,133,134,135 This conservation allows for the establishment of animal models and preclinical studies for saRNA-based therapies

In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)

Side effects Because the two medications have different active ingredients, they come with different potential side effects