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Platelet Activation and Thrombogenesis Platelet adhesion is a common trait of CVD ( Mice with short-term whole-body exposure to e-cigarettes developed a prothrombotic phenotype with hyperactive platelets and higher integrin and phosphatidylserine expression ( Conventional cigarettes and e-cigarettes produced a significant increase in platelet activation in non-smokers ( In vitro studies of platelet exposure to e-cigarette aerosol also found increases in CD40 and P-selectin ( in vivo studies, exposure to e-cigarettes for 57 days led to enhanced P-selectin levels after e-cigarette usage ( Clinical studies involving tobacco users with controlled conventional cigarette compared to e-cigarette with nicotine use showed acute increases in CD40 and P-selectin markers in conventional cigarette and e-cigarette users ( Vascular Trauma and Coronary Vascular Disease The effects of conventional cigarettes in vascular injury and CVD are well-established (184)

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