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Building upon the clinical use of bortezomib and the lessons learned from LTP001s trial termination and carfilzomibs PH-inducing effect, future efforts should prioritize advancing PROTACs technology and optimizing the safety profile of UPS-targeted agents

While the presence of NNAL at all indicated that participants still smoked cigarettes, the lower levels suggest that the e-cigarettes assisted in cutting back on their normal smoking levels, with the 5%-nicotine group experiencing greater reductions in exposure

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Also several limitations must be acknowledged