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MGF and Muscle Repair Contradictory Data A study by two pharmaceutical companies attempting to reproduce claimed satellite cell proliferation effects found that concentrations of MGF peptide up to 500 ng/ml failed to increase the proliferation of C2C12 cells or primary human skeletal muscle myoblasts while all cell types exhibited a proliferative response to mature IGF-1 or full-length IGF-1Eb calling into question whether discrete MGF peptide has a physiological role in this process and highlighting the importance of cell type, model system, and peptide formulation in MGF research design

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doi: 10.1016/j.theriogenology.2021.07.027 88 Ruiz-ConcaMGardelaJMogasTLpez-BjarMlvarez-RodrguezM