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As mentioned above, microglia, neurons, and astrocytes are involved in the pathological depression process

Mammalian neural stem cells

Spontaneously or enzymatically, due to the presence of mitochondrial matrix Mn-dependent superoxide dismutase (Mn-SOD), Cu-Zn-dependent superoxide dismutase (Cu,Zn-SOD) in the intermembrane space, O 2 may be converted into hydrogen peroxide (H 2 O 2 ), due to acceptance of an electron and two protons

In summary, from a technology standpoint, the field must continue improving encapsulation methods that are scalable, cost-effective, and reliable for mass production, ensuring that nano-formulated nutraceuticals can be manufactured consistently and economically without sacrificing performance