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The exposure of pulmonary fibroblasts to CSE led to damaged mitophagy, an increase in cell senescence, mtDNA damage, decreased mitochondrial membrane potential, and ATP levels, later restored by a specific mitochondrial antioxidant ( In addition, TGF- can also lead to mitophagy, stabilizing the mitophagy initiating protein PINK1 and inducing mtROS (78, 105)

This period may be longer if the outdoor temperature doesnt reach the required minimum of 18 C

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