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Most side effects fade as your body adjusts, and small changes handle the rest: Dry mouth: drink more water and chew sugar-free gum Trouble sleeping: take your dose early in the morning and limit caffeine after midday Faster heart rate: your provider checks your blood pressure and heart rate at follow-up visits

Cost Effectiveness The true cost is more than the sticker price

Thus, worldwide drug development efforts need re-evaluation and new strategies given that current efforts have been unsuccessful