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Medicines to help treat nosebleeds include: Aminocaproic acid (Amicar) helps slow the breakdown of blood clots Tranexamic acid (Lysteda) helps slow the breakdown of blood clots Desmopressin acetate (DDAVP, Stimate) increases clotting factors and helps blood to clot Afrin nasal spray constricts blood vessels in the nose to help stop bleeding Treating underlying health problems: Taking care of issues like bleeding disorders, high blood pressure, or sinus infections can help prevent nosebleeds