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In addition, the Notch pathway is essential for multiple biological processes in breast cancer cells, encompassing cell differentiation, apoptosis, and cell cycle progression (Farnie and Clarke, 2007)

Kemudian, melalui aksi katalitik GR, GSSG direduksi kembali menjadi GSH, sehingga mencapai regenerasi dan efek antioksidan yang berkelanjutan

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Thus, the loss of intracellular GSH in the presence of active generation of hydroperoxy-phospholipids could occur through several active mechanisms, including formation of GSH, export of GSSG, inadequate replenishment of GSH, or insufficient levels of GSSG reductase, each directly or indirectly dependent on the generation of hydroperoxy-phospholipids