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Niraparib: a poly(ADP-ribose) polymerase (PARP) inhibitor for the treatment of tumors with defective homologous recombination

J Am Med Assoc

Overcoming tumor resistance to immunotherapy Some investigators have reported on the use of nanoparticles to overcome resistance to immunotherapy, which remains a major challenge, particularly in the treatment of liver metastases, where activated hepatic stellate cells suppress T-cell infiltration and promote tumor growth by activating M2 macrophages and myeloid-derived suppressor cells

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