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The macrocycle 23 was selected as a proper research tool for more detailed studies since the molecule is convenient to prepare and due to its structural similarity to the IRAP substrates oxytocin and vasopressin in its N-terminal

FOXO4-DRI is a senolytic peptide that selectively induces apoptosis in senescent ('zombie') cells that accumulate with age and secrete harmful inflammatory factors

Research has focused on its anti-inflammatory effects particularly in gut tissue and skin inflammation models without causing immunosuppression, making it one of several compounds featured in our roundup of anti-inflammatory peptides

Reported rationale: less compounded peak nausea, smoother appetite suppression curve