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With that patented strain, 22nd Century subsequently created a series of very low nicotine content cigarette products called SPECTRUM that were exclusively provided to academic research institutions for use in clinical studies to assess the physiological and psychological effects of nicotine reduction in heavy smokers
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An Arizona pharmacy organisation, for example, voted in 1988 to ask Reynolds to voluntarily pull the cigarette, after the American Medical Association and several state-level medical groups said the device should be considered a ''new and hazardous system intended to deliver the drug nicotine," according to the New York Times
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