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By contrast, the present review seeks to provide an updated and integrative perspective by combining epidemiological evidence with mechanistic insights into airway inflammation, alveolar macrophage dysfunction, and carcinogen-mediated DNA damage

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Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, Galis ZS: Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro