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Clofazimine is at least partially metabolised in the liver via CYP3A4 and CYP1A2, thereby TB smokers may experience increased metabolite synthesis, potentially necessitating dosage adjustments

The UK is seeing a dramatic reduction in smoking at the moment and this tallies with recent findings that only 19% of 11 to 15-year-olds have ever tried a cigarette, so the good news is that we are on the right track. Prof Hajek added: Concerns were expressed that e-cigarettes could be as addictive as conventional cigarettes, but this has not been the case

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