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Peripheral and cochlear mechanisms include N-methyl-D-aspartate receptor activation, 62 altered operating points of outer hair cells, 63 stereociliary detachment, 64 and elevated intracochlear potentials

Biochim Biophys Acta 994:180186 Clavreul N, Bachschmid MM, Hou X, Shi C, Idrizovic A, Ido Y, Pimentel D, Cohen RA (2006) S-glutathiolation of p21ras by peroxynitrite mediates endothelial insulin resistance caused by oxidized low-density lipoprotein

ii) increased AMPK also inhibits mitochondrial glycerol-3-phosphate dehydrogenase (mGPD), leading to an increase in cytosolic NADH, which both stimulates the conversion of pyruvate to lactate, and simultaneously decreases gluconeogenesis

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