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Endometrial thickening (a sign of endometrial health) and reduced adhesions were noted after three months, and after 30 months 10 women had become pregnant: eight pregnancies resulted in healthy childbirth, one pregnancy was ongoing, and one miscarriage had occurred

However, the prevailing biological hypothesis for konzo development is that famine-stricken populations rely on diets that are deficient in the key sulfur amino acids methionine and cysteine, likely decreasing their ability to fully detoxify cyanide 10,11

These treatments mainly work by boosting dopamine signaling in the brain, or by altering the activity of other neurotransmitters that help control movement

Specifically, NCX4040 treatment led to increased reactive oxygen species (ROS), lipid peroxidation, and activation of ferroptosis-related genes such as CHAC1 , GPX4 , and NOX4