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Additionally, studies suggest that AChE overexpression disrupts the glutaminergic system, resulting in damage to synaptic structures and excitatory structures [107]

Reference Gao, Ganocy and Conroy9,Reference Temmingh, Williams, Siegfried and Stein12,Reference Baker, Hides and Lubman13 Similarly, psychosocial interventions such as motivational interviewing, cognitivebehavioural therapy and contingency management have only shown small, short-term effects Reference Buckner, Zvolensky, Ecker, Schmidt, Lewis and Paulus14 or no effect at all in people with SMI

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