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The study also investigated the role of IL-6, an immune system marker regulating sleep, finding its levels positively associated with microbiota diversity and various sleep metrics, including time in bed and total sleep duration

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doi: 10.1055/s-0043-109099 100 MoranCPhanTGChenJBlizzardLBeareRVennAet al

For example, sugar alcohols like sorbitol or mannitol (used in some chewable or effervescent preparations) can have osmotic effects, drawing water into the intestinal lumen and potentially leading to loose stools in sensitive individuals