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Mendelian randomisation (MR) analysis In the present study, a modified Mendelian randomisation approach was performed to investigate a potential causal relationship 36,65 , in which non-pleiotropic polygenic risk scores (i.e., the valid-PRS) were established as instrument variables of randomised experiments for potential causal inference

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In some countries, as many as 52% of men and 22% of women smoke

Emergency Warning Signs: When to Act Fast Call 911 or go to ER immediately if you experience: Suicidal thoughts or plans New or worsening seizures Serotonin syndrome signs (fever, confusion, rapid heart rate, tremor, muscle stiffness) Severe allergic reaction (rash, swelling, trouble breathing) Fast, irregular heartbeat or fainting Call your doctor urgently if: Unusual bleeding or bruising Severe anxiety, panic, or agitation Worsening depression New-onset confusion or hallucinations Poison Control: 1-800-222-1222 Suicide & Crisis Lifeline: 988 Summary & Next Steps Key takeaways: Nausea (15%), headache (24%), and sexual dysfunction (14%+) are the most common side effects of escitalopram, with real-world users highlighting additional problems like fatigue (reported as moderate/severe by 3/6 users) and emotional blunting