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Hypomethylation of LINE-1 repeat elements and global loss of DNA hydroxymethylation in vapers and smokers

The majority of the evidence concerning lung cancer risks in lifelong nonsmokers in the UK indicates that they are similar to those seen in the American Cancer Society (ACS) prospective study, corresponding to a cumulative risk by age 75 of around 0.4% (Peto et al, 1992), suggesting that the low number of nonsmokers observed in the study was a chance finding

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