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Tobacco smoke contains more than 70 harmful chemicals that can damage DNA and increase the risk of developing cancers such as Lung Cancer, Throat Cancer, and Oral Cancer

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Due to respiratory failure and shortness of breath after activity in patients with COPD, reduced physical exercise ability becomes an important cause of bone mass loss [68]

Although cigarette smoking was found to be the major preventable cause of lung cancer, emphysema, and heart disease by the 1950s, a significant decline in smoking among minority groups did not occur in the 20th century