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In parallel, taxes on cigarettes and strict restrictions on the marketing of these products have played an important role. Philip Morris International America CEO Martin King on how the cigarette giant is preparing for a future when no one smokes

[6] When carbon monoxide enters the bloodstream, it takes the place of oxygen, meaning less oxygen is getting transported to your vital organs

This is predictable, because the higher dose of nicotine delivered by e-cigarettes can effectively surmount nicotine tolerance, satisfying the drive for a nicotine "buzz." Switching to e-cigarettes would only be harm-reducing if the products cause less health damage than traditional cigarettes

What remains are habitbased cravings, which fade gradually over the next few months