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The molecular mechanisms regulating the expression of some of these immune checkpoints involve different subtypes of nAChR receptors, which activate the STAT3 pathway (69, Interestingly, nicotine has been demonstrated to regulate processes such as immune evasion, proliferation, metastases, and stem cell-like characteristics via immune checkpoints in association with nAChR receptors in the cancer context ( in vitro and murine models

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