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Behrn Inhalation of vapor from black pepper extract reduces smoking withdrawal symptoms (published in Drug and Alcohol Dependence 34 (1994) 225-229), the authors belonging at 'Nicotine Research Laboratory, VA Medical Center and Department of Psychiatry of Duke University, USA' focused on a substitute cigarette device, namely a puff tube based on essential oil of black pepper ( piper nigrum )

Often mixed with Burley for a balanced taste