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It is studied as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme linked to metabolic and oncogenic pathways in research models

The single best reason to take a vitamin B12 supplement is to prevent vitamin B12 deficiency which can lead to a number of symptoms and even long-term health issues, such as chronic fatigue, mood disorders, neurodegenerative disorders, heart issues, anemia and neural tube defects in infants

This depends on factors like your diet, level of deficiency, general health status, and whether or not you have any symptoms

The absorption of vitamin B12 is fraught with hurdles: In the stomach, vitamin B12 needs to bind with a protein called Intrinsic Factor to absorb, plus sufficient acid to release it from protein foods