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In insulin resistance, the body does not respond to the increasing insulin levels, therefore causing the excess glucose in the blood to be taken up by the liver and converted to fat, increasing overall fatty tissue

dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies

Before reconstitution, lyophilized peptide vials should be stored in a freezer for long-term stability