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With hundreds of published studies, it is one of the most researched peptides in regenerative biology demonstrating systemic activity across tendons, ligaments, muscle, bone, gut epithelium, and neural tissue through the nitric oxide system, growth hormone receptor signaling, and angiogenic pathways

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One important caveat: wound serum from chronic wounds (such as diabetic ulcers) contains enzymes that break down GHK-Cu, which may limit topical efficacy on infected or chronic wounds