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Interestingly, the greatest differences in the composition and abundance of the metabolomes between smokers and non-smokers were among biogenic amines, including, cadaverine (fold change in non-smokers, FC = 53.19), putrescine (FC = 15.80), agmatine (FC = 15.49), tyramine (FC = 5.15) and tryptamine (FC = 4.43), which were much higher in smokers (Table S2, Figure S2)

In addition to this, nicotine is a risk factor for cardiovascular disease through its well-known effects on endothelial function and stimulation of inflammatory markers such as C-reactive protein 67,68