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A 23-year-old bodybuilder in Russia, who has been nicknamed Popeye due to his abnormally large biceps, has recently undergone the first of at least three surgeries to remove roughly 3 pounds of dead muscle tissue after he injected a dangerous enhancement substance Synthol into his biceps and triceps

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Although much of the evidence described above come from cellular fractionation studies that will need validation, these findings may explain the mitochondrial dysfunction reported in in vitro and in vivo SCA3 models, namely mtDNA deletions and reduced copy number that are often found in SCA3 cells, transgenic mice, and patients