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If proposing alternative text and images to those in this proposed rule, please provide scientific information supporting that the alternative text and images would, in fact, promote greater public understanding of the negative health consequences of smoking

In models of 3-methylcholanthrene-induced carcinogenesis, it was IL-1, rather than IL-1 in the tumor microenvironment that was capable of determining the invasive potential of malignant cells, including increased tumor adhesion and invasion, angiogenesis and immune suppression (104)

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Flow cytometry analysis was performed using Cytobank (Beckman Coulter)